Search results for "Proto-Oncogene Proteins c-myb"

showing 2 items of 2 documents

Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein

2019

JBC papers in press xx, 16604-16619 (2019). doi:10.1074/jbc.RA119.009845

0301 basic medicineendocrine systemCircadian clockTranscription factor complex610BiochemistryProtein Structure SecondaryProtein–protein interaction03 medical and health sciencesTransactivationMiceProto-Oncogene Proteins c-mybProtein DomainsX-Ray DiffractionCircadian ClocksScattering Small AngleAnimalsddc:610Amino Acid SequenceCREB-binding proteinMolecular BiologyTernary complexTranscription factorBinding Sites030102 biochemistry & molecular biologybiologyChemistryARNTL Transcription FactorsCell BiologyHistone-Lysine N-MethyltransferaseSurface Plasmon ResonanceCREB-Binding ProteinRecombinant ProteinsCell biologyProtein Structure Tertiary030104 developmental biologyStructural biologyProtein Structure and Foldingbiology.proteinMutagenesis Site-DirectedMyeloid-Lymphoid Leukemia ProteinProtein Binding
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QSAR of Natural Sesquiterpene Lactones as Inhibitors of Myb-dependent Gene Expression

2017

Background Protein c-Myb is a therapeutic target. Some sesquiterpene lactones suppress Myb-dependent gene expression, which results in their potential anti-cancer activity. Material & methods Database ChEMBL is a representative of lactones for physicochemical and physiochemical properties. Data presented for 31 natural lactones are discussed in terms of quantitative structureactivity relationships with the objective to predict inhibitors of Myb-induced gene expression. Several constitutional descriptors are related to structure-activity. α-Methylene-γ-lactone groups enhance while OH functions worsen potency. The latter feature is in agreement with the fact that the more lipophilic the lacto…

Models Molecular0301 basic medicine030103 biophysicsQuantitative structure–activity relationshipStereochemistryQuantitative Structure-Activity RelationshipSesquiterpene lactoneSesquiterpeneLactonesProto-Oncogene Proteins c-myb03 medical and health scienceschemistry.chemical_compoundDrug DiscoveryGene expressionHumansStructure–activity relationshipMYBCytotoxicitychemistry.chemical_classificationBiological ProductsDose-Response Relationship DrugMolecular StructureCationic polymerizationGeneral MedicinechEMBLGene Expression RegulationchemistrySesquiterpenesLactoneCurrent Topics in Medicinal Chemistry
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